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KMID : 0043319960190040292
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Archives of Pharmacal Research
1996 Volume.19 No. 4 p.292 ~ p.296
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Metabolism of glycyrrhizin and baicalin by human intestinal bacteria
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Kim Dong-Hyun
Jang Il-Sung
Lee Hyeong-Kyu
Jung Eun-Ah
Lee Kyeu-Yup
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Abstract
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By human intestinal bacteria, glycyrrhizin (18-glycyrrhetic acid -D-glucuronyl.-D-glucuronic acid, GL) and baicalin (baicalein -D-glucuronic acid) were metabolized to glycyrrhetinic acid and baicalin, respectively. However, .-glucuronidase of Bacteroides JY-6 isolated from human intestinal bacteria hydrolyzed GL or 18.-glycyrrhetinic acid ..-D-glucuronic acid to 18-glycyrrhetic acid but did not baicalin. However, E. coli -glucironidase from human intestinal bacteria hydrolyzed baicalin to baicalein, but did not GL.-Glucuronidase of mammalian tissues hydrolyzed both GL and baicalin.
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KEYWORD
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Glycyrrhizin, lntesinal bacteria, Baicalin Bacteriodes J-37
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